Hector Santiago
| Date | Team | Opponent | Result | IP | H | R | ER | BB | SO | PA | 2B | 3B | HR | GO | FO | MISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2021-06-01 | SEA | vs. OAK | L, 12-6 | 2.2 | 3 | 3 | 3 | 1 | 2 | 12 | 2 | 0 | 0 | 3 | 3 | RP |
| 2021-06-04 | SEA | @ LAA | L, 3-2 | 3.0 | 2 | 1 | 1 | 1 | 5 | 12 | 0 | 0 | 1 | 3 | 1 | RP, L |
| 2021-06-08 | SEA | @ DET | L, 5-3 | 2.0 | 1 | 0 | 0 | 1 | 3 | 8 | 1 | 0 | 0 | 2 | 1 | RP |
| 2021-06-10 | SEA | @ DET | L, 8-3 | 1.0 | 1 | 0 | 0 | 1 | 1 | 5 | 1 | 0 | 0 | 0 | 2 | RP |
| 2021-06-11 | SEA | @ CLE | L, 7-0 | 2.0 | 1 | 0 | 0 | 1 | 3 | 8 | 1 | 0 | 0 | 2 | 1 | RP |
| 2021-06-16 | SEA | vs. MIN | L, 7-2 | 2.0 | 1 | 0 | 0 | 0 | 1 | 7 | 0 | 0 | 0 | 3 | 2 | RP |
| 2021-06-17 | SEA | vs. TBR | W, 6-5 | 1.0 | 1 | 0 | 0 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | RP, W |
| 2021-06-23 | SEA | vs. COL | L, 5-2 | 1.0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 1 | RP |
| 2021-06-26 | SEA | @ CHW | W, 3-2 | 2.1 | 3 | 1 | 1 | 2 | 4 | 12 | 0 | 0 | 0 | 1 | 2 | RP |
| 2021-07-02 | SEA | vs. TEX | W, 5-4 | 1.0 | 1 | 0 | 0 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | RP |
| 2021-07-06 | SEA | vs. NYY | L, 12-1 | 3.1 | 7 | 3 | 3 | 2 | 2 | 19 | 1 | 0 | 0 | 2 | 6 | RP |
| 2021-07-11 | SEA | vs. LAA | L, 7-1 | 3.0 | 2 | 1 | 1 | 1 | 1 | 12 | 1 | 0 | 1 | 5 | 3 | SP |
| 2021-07-27 | SEA | vs. HOU | L, 8-6 | 2.0 | 4 | 1 | 1 | 1 | 1 | 11 | 1 | 0 | 0 | 1 | 3 | RP |
| Date | Team | Opponent | Result | IP | H | R | ER | BB | SO | PA | 2B | 3B | HR | GO | FO | MISC |
| Totals, 13 G | SEA | 12 Teams | 3 - 10 | 26.1 | 27 | 10 | 10 | 11 | 30 | 117 | 8 | 0 | 2 | 23 | 25 | 1 - 1, 1 GS |
| 162 Game Avg. | 128.0 | 131 | 49 | 49 | 53 | 146 | 568 | 39 | 0 | 10 | 112 | 121 |