Luis Castillo
| Date | Team | Opponent | Result | IP | H | R | ER | BB | SO | PA | 2B | 3B | HR | GO | FO | MISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2021-04-01 | CIN | vs. STL | L, 11-6 | 3.1 | 8 | 10 | 8 | 2 | 0 | 21 | 1 | 0 | 1 | 5 | 4 | SP, L |
| 2021-04-07 | CIN | vs. PIT | W, 11-4 | 7.0 | 4 | 0 | 0 | 1 | 5 | 25 | 2 | 0 | 0 | 8 | 6 | SP, W |
| 2021-04-13 | CIN | @ SFG | L, 7-6 | 5.0 | 7 | 4 | 4 | 0 | 7 | 21 | 1 | 0 | 2 | 3 | 4 | SP |
| 2021-04-20 | CIN | vs. ARI | L, 5-4 | 4.0 | 7 | 3 | 1 | 3 | 4 | 23 | 2 | 0 | 0 | 3 | 3 | SP |
| 2021-04-25 | CIN | @ STL | L, 5-2 | 5.0 | 6 | 4 | 4 | 1 | 3 | 21 | 0 | 0 | 2 | 9 | 1 | SP, L |
| 2021-05-01 | CIN | vs. CHC | L, 3-2 | 5.1 | 8 | 3 | 3 | 1 | 5 | 23 | 2 | 0 | 0 | 6 | 2 | SP, L |
| 2021-05-08 | CIN | @ CLE | L, 9-2 | 4.0 | 5 | 6 | 4 | 2 | 2 | 21 | 1 | 1 | 0 | 5 | 4 | SP, L |
| 2021-05-13 | CIN | @ COL | L, 13-8 | 3.2 | 10 | 8 | 8 | 2 | 3 | 23 | 2 | 0 | 1 | 4 | 3 | SP, L |
| 2021-05-18 | CIN | vs. SFG | L, 4-2 | 5.0 | 6 | 3 | 3 | 3 | 11 | 24 | 2 | 0 | 1 | 2 | 1 | SP, L |
| 2021-05-23 | CIN | vs. MIL | L, 9-4 | 5.0 | 5 | 5 | 5 | 4 | 5 | 24 | 1 | 0 | 1 | 4 | 6 | SP, L |
| 2021-05-29 | CIN | @ CHC | L, 10-2 | 5.0 | 4 | 4 | 2 | 4 | 3 | 23 | 0 | 0 | 0 | 4 | 5 | SP, L |
| 2021-06-04 | CIN | @ STL | W, 6-4 | 6.0 | 3 | 1 | 1 | 1 | 5 | 23 | 0 | 0 | 1 | 5 | 8 | SP, W |
| 2021-06-10 | CIN | vs. MIL | L, 7-2 | 5.2 | 1 | 3 | 3 | 3 | 7 | 22 | 0 | 0 | 0 | 8 | 2 | SP, L |
| 2021-06-15 | CIN | @ MIL | W, 2-1 | 7.0 | 3 | 0 | 0 | 3 | 7 | 26 | 0 | 0 | 0 | 9 | 2 | SP |
| 2021-06-20 | CIN | @ SDP | L, 3-2 | 6.0 | 6 | 3 | 2 | 3 | 7 | 26 | 0 | 1 | 0 | 5 | 4 | SP, L |
| 2021-06-26 | CIN | vs. ATL | W, 4-1 | 7.0 | 6 | 0 | 0 | 2 | 6 | 28 | 2 | 0 | 0 | 9 | 5 | SP, W |
| 2021-07-01 | CIN | vs. SDP | W, 5-4 | 6.1 | 5 | 3 | 3 | 3 | 6 | 26 | 1 | 0 | 0 | 6 | 6 | SP |
| 2021-07-06 | CIN | @ KCR | L, 7-6 | 7.0 | 3 | 1 | 1 | 1 | 4 | 25 | 0 | 0 | 1 | 10 | 6 | SP |
| 2021-07-11 | CIN | @ MIL | W, 3-1 | 5.1 | 3 | 1 | 1 | 6 | 6 | 24 | 0 | 0 | 0 | 4 | 5 | SP |
| 2021-07-17 | CIN | vs. MIL | L, 7-4 | 6.0 | 5 | 0 | 0 | 3 | 8 | 26 | 0 | 0 | 0 | 6 | 3 | SP |
| 2021-07-24 | CIN | vs. STL | W, 5-3 | 7.0 | 5 | 1 | 1 | 3 | 9 | 28 | 1 | 0 | 0 | 6 | 4 | SP, W |
| 2021-07-29 | CIN | @ CHC | W, 7-4 | 6.0 | 7 | 3 | 3 | 2 | 8 | 24 | 0 | 0 | 2 | 5 | 2 | SP, W |
| 2021-08-04 | CIN | vs. MIN | W, 6-5 | 6.0 | 6 | 1 | 1 | 1 | 7 | 24 | 1 | 0 | 1 | 8 | 2 | SP, W |
| 2021-08-09 | CIN | @ CLE | L, 9-3 | 3.1 | 7 | 8 | 8 | 3 | 2 | 21 | 1 | 2 | 2 | 6 | 2 | SP, L |
| 2021-08-14 | CIN | @ PHI | L, 6-1 | 6.2 | 5 | 3 | 3 | 2 | 8 | 27 | 1 | 0 | 1 | 7 | 4 | SP, L |
| 2021-08-19 | CIN | vs. MIA | W, 6-1 | 7.0 | 8 | 1 | 1 | 1 | 7 | 28 | 2 | 0 | 0 | 7 | 5 | SP, W |
| 2021-08-25 | CIN | @ MIL | L, 4-1 | 6.1 | 4 | 2 | 2 | 2 | 6 | 25 | 3 | 0 | 0 | 9 | 2 | SP, L |
| 2021-08-30 | CIN | vs. STL | L, 3-1 | 6.0 | 5 | 3 | 3 | 2 | 8 | 24 | 2 | 0 | 1 | 7 | 2 | SP, L |
| 2021-09-05 | CIN | vs. DET | L, 4-1 | 6.0 | 4 | 3 | 1 | 2 | 7 | 24 | 1 | 1 | 0 | 4 | 6 | SP, L |
| 2021-09-11 | CIN | @ STL | L, 6-4 | 7.0 | 8 | 4 | 4 | 1 | 5 | 27 | 2 | 1 | 1 | 10 | 2 | SP |
| 2021-09-17 | CIN | vs. LAD | W, 3-1 | 6.1 | 5 | 0 | 0 | 2 | 10 | 26 | 1 | 0 | 0 | 7 | 2 | SP, W |
| 2021-09-23 | CIN | vs. WAS | L, 3-2 | 6.0 | 6 | 2 | 2 | 3 | 6 | 27 | 2 | 0 | 1 | 5 | 7 | SP, L |
| 2021-10-01 | CIN | @ PIT | L, 9-2 | 5.1 | 6 | 1 | 1 | 3 | 5 | 23 | 0 | 1 | 0 | 8 | 0 | SP |
| Date | Team | Opponent | Result | IP | H | R | ER | BB | SO | PA | 2B | 3B | HR | GO | FO | MISC |
| Totals, 33 G | CIN | 23 Teams | 11 - 22 | 187.2 | 181 | 94 | 83 | 75 | 192 | 803 | 34 | 7 | 19 | 204 | 120 | 8 - 16, 33 GS |
| 162 Game Avg. | 193.1 | 186 | 97 | 86 | 77 | 198 | 827 | 35 | 7 | 20 | 210 | 124 |