Luis Castillo
| Date | Team | Opponent | Result | IP | H | R | ER | BB | SO | PA | 2B | 3B | HR | GO | FO | MISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2022-05-09 | CIN | vs. MIL | W, 10-5 | 4.2 | 3 | 3 | 3 | 3 | 5 | 20 | 1 | 0 | 1 | 3 | 5 | SP |
| 2022-05-14 | CIN | @ PIT | L, 3-1 | 5.0 | 4 | 3 | 3 | 1 | 2 | 19 | 0 | 0 | 1 | 6 | 5 | SP, L |
| 2022-05-20 | CIN | @ TOR | L, 2-1 | 6.0 | 7 | 2 | 2 | 0 | 5 | 25 | 3 | 0 | 0 | 7 | 5 | SP, L |
| 2022-05-25 | CIN | vs. CHC | W, 4-3 | 5.0 | 4 | 2 | 2 | 1 | 6 | 20 | 2 | 0 | 0 | 5 | 4 | SP, W |
| 2022-05-31 | CIN | @ BOS | W, 2-1 | 6.0 | 1 | 0 | 0 | 3 | 10 | 21 | 0 | 0 | 0 | 3 | 4 | SP, W |
| 2022-06-05 | CIN | vs. WAS | L, 5-4 | 6.1 | 6 | 5 | 3 | 4 | 6 | 30 | 2 | 0 | 1 | 6 | 7 | SP, L |
| 2022-06-10 | CIN | @ STL | L, 2-0 | 6.0 | 6 | 2 | 1 | 1 | 3 | 26 | 0 | 0 | 0 | 4 | 11 | SP, L |
| 2022-06-15 | CIN | @ ARI | L, 7-4 | 7.0 | 4 | 3 | 3 | 2 | 6 | 28 | 3 | 0 | 1 | 8 | 5 | SP |
| 2022-06-22 | CIN | vs. LAD | L, 8-4 | 5.0 | 5 | 4 | 4 | 3 | 6 | 25 | 1 | 0 | 0 | 5 | 4 | SP |
| 2022-06-28 | CIN | @ CHC | W, 5-3 | 6.0 | 5 | 0 | 0 | 3 | 11 | 25 | 0 | 0 | 0 | 1 | 4 | SP, W |
| 2022-07-03 | CIN | vs. ATL | W, 4-3 | 7.0 | 6 | 1 | 1 | 1 | 6 | 28 | 1 | 0 | 1 | 9 | 6 | SP |
| 2022-07-08 | CIN | vs. TBR | W, 2-1 | 7.0 | 4 | 1 | 1 | 1 | 8 | 26 | 1 | 0 | 0 | 10 | 3 | SP |
| 2022-07-14 | CIN | @ NYY | W, 7-6 | 7.0 | 2 | 1 | 1 | 4 | 8 | 28 | 1 | 0 | 0 | 5 | 8 | SP |
| 2022-07-27 | CIN | vs. MIA | W, 5-3 | 7.0 | 6 | 3 | 3 | 1 | 8 | 28 | 1 | 0 | 2 | 6 | 7 | SP, W |
| 2022-08-03 | SEA | @ NYY | W, 7-3 | 6.2 | 5 | 3 | 3 | 3 | 8 | 27 | 2 | 0 | 1 | 3 | 8 | SP, W |
| 2022-08-09 | SEA | vs. NYY | W, 1-0 | 8.0 | 3 | 0 | 0 | 2 | 7 | 27 | 0 | 0 | 0 | 7 | 8 | SP |
| 2022-08-15 | SEA | @ LAA | W, 6-2 | 6.0 | 6 | 2 | 2 | 1 | 9 | 25 | 1 | 0 | 1 | 5 | 2 | SP |
| 2022-08-21 | SEA | @ OAK | L, 5-3 | 5.0 | 8 | 4 | 4 | 1 | 5 | 23 | 3 | 0 | 0 | 4 | 3 | SP, L |
| 2022-08-27 | SEA | vs. CLE | L, 4-3 | 6.0 | 4 | 1 | 1 | 1 | 10 | 24 | 0 | 0 | 1 | 6 | 3 | SP |
| 2022-09-02 | SEA | @ CLE | W, 6-1 | 6.0 | 5 | 0 | 0 | 1 | 4 | 24 | 0 | 0 | 0 | 7 | 6 | SP, W |
| 2022-09-07 | SEA | vs. CHW | L, 9-6 | 5.2 | 5 | 6 | 3 | 1 | 8 | 24 | 2 | 0 | 1 | 4 | 5 | SP |
| 2022-09-14 | SEA | vs. SDP | W, 6-1 | 6.0 | 4 | 0 | 0 | 1 | 9 | 24 | 0 | 0 | 0 | 3 | 6 | SP, W |
| 2022-09-20 | SEA | @ OAK | L, 4-1 | 4.2 | 6 | 4 | 4 | 2 | 4 | 22 | 2 | 0 | 1 | 6 | 4 | SP, L |
| 2022-09-25 | SEA | @ KCR | L, 13-12 | 5.1 | 7 | 5 | 5 | 3 | 5 | 25 | 2 | 0 | 1 | 5 | 5 | SP |
| 2022-10-01 | SEA | vs. OAK | W, 5-1 | 6.0 | 2 | 1 | 1 | 1 | 8 | 21 | 0 | 0 | 0 | 6 | 3 | SP, W |
| 2022-10-07 | SEA | @ TOR | W, 4-0 | 7.1 | 6 | 0 | 0 | 0 | 5 | 28 | 0 | 0 | 0 | 7 | 9 | SP, W |
| 2022-10-13 | SEA | @ HOU | L, 4-2 | 7.0 | 5 | 3 | 3 | 0 | 7 | 26 | 2 | 0 | 2 | 4 | 10 | SP, L |
| Total Games: 27 | ||||||||||||||||